doramectin
Enable an agent to identify doramectin, assess the quality and condition of a material containing it, and determine which handling or veterinary-use decisions require further evidence.
Bundle → Layer → Finding → Questions Filled
6 bundles · 11 layers · 17 findings · 31 questions
Doramectin identity Establish the precise chemical entity represented by the registry entry.
Molecular definition
Resolve the structure and identifiers that define doramectin.
Structure and identifier agreement
Require agreement among the accepted stereochemical structure, chemical name and identifier records.
- Which stereochemical structure and canonical identifiers define doramectin for this registry entry? definition
- Which authoritative records support the CAS, PubChem and EC mappings, and do their structures agree? provenance
Related-compound boundaries
Separate doramectin from neighbouring substances and formulated medicines.
Identity discrimination
Define the evidence needed to distinguish the intact active substance from related avermectins, epimers and products.
- Which structural and analytical features distinguish doramectin from ivermectin, abamectin and doramectin epimers? boundary
- Does the assessed sample represent bulk doramectin, a reference standard or a finished formulation? boundary
Doramectin material quality Assess whether a particular lot supports its declared identity, grade and intended use.
Grade and lot evidence
Connect the material to specifications and traceable quality records.
Grade qualification
Record the declared grade, lot provenance and evidence supporting acceptance.
- Which specification governs this doramectin lot, and which intended uses does it support? boundary
- Which manufacturer, lot record and certificate of analysis establish its provenance? provenance
Assay and impurities
Establish active content and resolve substances that compromise quality.
Analytical quality assessment
Evaluate assay basis, related substances, water and residual solvents without equating peak area with mass purity.
- What doramectin content is measured, on what basis, and with what reference standard and uncertainty? measurement
- Which related substances, residual solvents and water levels are measured, and does the method resolve relevant epimers and degradation products? measurement
- Do the results justify accepting the lot, further testing it or withholding it from the intended use? action
Doramectin physical state and stability Characterize the material under explicit physical and storage conditions.
Phase and solution behavior
Capture condition-dependent properties needed for identification and preparation.
Measured physical properties
Record observed solid form, thermal behavior and solvent-specific solubility with experimental context.
- What phase, solid form and melting or decomposition behavior are experimentally established for the assessed doramectin material? measurement
- What solubility and partitioning measurements exist, and which solvent, temperature and pH conditions apply? measurement
Degradation and storage
Relate exposure history to retained identity and quality.
Stability-supported condition
Use material-specific stability evidence to assess storage, preparation and retest decisions.
- Which light, temperature, moisture or oxidation exposures change doramectin assay or impurity levels? measurement
- Which storage and retest conditions are supported for this bulk grade or prepared analytical solution? provenance
- What evidence is required to assess a storage excursion before continued use? action
Doramectin antiparasitic activity Connect biological activity to parasite targets and the conditions under which effects were demonstrated.
Mechanism and spectrum
Separate mechanistic evidence from demonstrated parasite control.
Target-specific activity
The product label describes chloride-channel modulation in nematodes and arthropods; the model must distinguish class-level mechanism from doramectin-specific evidence. [Dectomax label](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=44b8a743-4f00-457a-8b7e-5f3a557c04f1)
- Which molecular-target studies directly establish doramectin activity rather than infer it from the macrocyclic-lactone class? provenance
- Which parasite species and life stages have measured susceptibility, using which endpoints and exposures? measurement
Exposure and resistance
Qualify activity by achieved exposure and parasite population.
Effectiveness transfer limits
Require supporting evidence before transferring efficacy between formulations, routes, hosts or parasite populations.
- Which host, formulation and route produced the exposure underlying the reported effect? boundary
- What doramectin susceptibility or resistance evidence exists for the relevant parasite population, including cross-resistance testing? measurement
Doramectin safety and permitted use Identify material handling constraints, environmental concerns and the external records governing veterinary use.
Handling and environment
Evaluate exposure pathways for bulk material, contaminated waste and excreted residues.
Exposure controls
Capture material-specific hazards alongside environmental evidence; the product label identifies aquatic-organism and dung-insect concerns. [Dectomax label](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=44b8a743-4f00-457a-8b7e-5f3a557c04f1)
- Which dated SDS establishes the applicable GHS classifications, handling controls and any occupational exposure limit for this material? provenance
- What measured fate and toxicity endpoints describe doramectin in soil, water, sediment and dung? measurement
- Which containment and disposal measures address the actual material and release pathway? action
Authorization and residue links
Link the substance to dated product permissions and food-residue assessments.
Contextual use constraints
Treat authorization, host restrictions and withdrawal periods as jurisdiction- and product-dependent evidence rather than universal substance constants.
- Which current authority record covers the proposed product, jurisdiction, host class, route and indication? provenance
- Which marker-residue definition, tissue or milk limit and product-specific withdrawal evidence apply? boundary
- Which unresolved authorization or residue condition must be settled before the linked treatment model can proceed? action
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.
Reported evidence
Findings from the breadth pass, kept separate from the structural claims.
Check these first
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these check these first hold for the sense of doramectin this model covers, and on what evidence? provenance
Identifiers and schemes
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these identifiers and schemes hold for the sense of doramectin this model covers, and on what evidence? provenance
Real-world use
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these real-world use hold for the sense of doramectin this model covers, and on what evidence? provenance
Typical measurements
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these typical measurements hold for the sense of doramectin this model covers, and on what evidence? provenance
Failure modes and hazards
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these failure modes and hazards hold for the sense of doramectin this model covers, and on what evidence? provenance
Regional variation
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these regional variation hold for the sense of doramectin this model covers, and on what evidence? provenance
Neighbouring kinds and how to tell them apart
Recalled without web access and unsourced; every item is a lead to verify.
- Which of these neighbouring kinds and how to tell them apart hold for the sense of doramectin this model covers, and on what evidence? provenance
Classifiers Filled
- Family
- Thing Registry
- Category
- Physical world and living systems
- Entry kind
- thing
- Plane
- PHY
- Domain
- PHY.MAT
What it is Filled
Doramectin is an avermectin-class macrocyclic lactone used as a veterinary antiparasitic active substance against susceptible nematodes and arthropod parasites.
In scope
- Doramectin molecular identity, stereochemistry and identifier reconciliation
- Bulk substance and reference-standard grades, assay and related impurities
- Physical properties, stability and storage conditions with measurement context
- Antiparasitic activity and evidence of susceptibility or resistance
- Substance hazards, environmental fate and links to veterinary authorizations
Out of scope
- Finished injectable or pour-on products, their excipients and packaging
- Individual animal diagnosis, prescribing and treatment administration
- Fermentation equipment and manufacturing-process operation
- Parasite taxonomy and complete parasite life-cycle models
- Farm parasite-control programs and food-product release decisions
Why it exists Filled
Enable an agent to identify doramectin, assess the quality and condition of a material containing it, and determine which handling or veterinary-use decisions require further evidence.
Distinguishing features Filled
- Match the complete stereochemical structure and CAS 117704-25-3; the formula C50H74O14 alone cannot establish identity. [KEGG doramectin record](https://www.kegg.jp/entry/D01129)
- Require an analytical identity test that distinguishes doramectin from ivermectin, abamectin and other related macrocyclic lactones.
- Check whether the record describes the active substance or a formulated medicine: Dectomax injection contains doramectin plus formulation ingredients. [Dectomax label](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=44b8a743-4f00-457a-8b7e-5f3a557c04f1)
- Distinguish intact doramectin from epimers, degradation products and metabolites using a method capable of resolving the relevant species.
What robots and AI may and may not do Filled
Must not
- Recommend it or a dose for an animal without a veterinarian's direction.
- Advise using livestock products on dogs, especially breeds sensitive to avermectins.
- Advise selling meat or milk from treated animals before the withdrawal period ends.
- Advise disposing of it where it can reach water or dung fauna.
Only with a human decision
- Any decision to treat an animal or a herd with it.
May
- Describe doramectin and its approved veterinary uses from regulatory sources.
- Report withdrawal periods for meat and milk as stated on the product label.
Moral aspects Filled
- Wrong use can kill sensitive dogs and leave residues in food.
- Avermectins harm dung beetles and aquatic life that farmland depends on.
Who is affected
- Treated animals
- Dogs of sensitive breeds
- Consumers
- Dung beetles and aquatic life
Owners Filled
Steward
The marketing authorization holder; veterinary medicines regulators and veterinarians control its use.
Master systems
- Veterinary medicines product registers
Links to other meta-models Filled
parent
- Q422687 - registry parent class
What else AI and robots need to interact with it Filled
Identity and identifiers required Filled
- Vercy registry: vr.tr.doramectin
- Wikidata: Q906534 (https://www.wikidata.org/wiki/Q906534)
Direct properties required Filled
- Chemical identity: CAS 117704-25-3; formula C50H74O14; stereochemical structure and verified database identifiers
- Material grade: Veterinary API, analytical reference standard, research material or unspecified; governing specification
- Doramectin assay: % mass fraction, with as-is or dry basis and analytical method
- Related-substance profile: Individual and total impurities in % or mg/kg; identities, detection limits and method
- Physical form and thermal behavior: Observed phase and solid form; transition or decomposition temperature in °C with method
- Solubility and partitioning: Solubility in mg/L with solvent, temperature and pH; partition coefficient with method
- Stability status: Within supported storage period, excursion pending assessment, degraded or unassessed
- Parasite susceptibility: Parasite species, life stage and population linked to assay endpoint, exposure and result
- Hazard and authorization evidence: Dated SDS classifications, exposure limits and authority records linked to material or product scope
Recognition required Filled
- Supplied as injectable solutions or pour-on liquids for livestock; identified by label.
Capabilities and actions required Filled
- Reconcile a supplier material or analytical result with the registered doramectin identity.
- Assess a lot against its declared doramectin grade and impurity specification.
- Select a supported analytical preparation and identity or assay method.
- Flag storage excursions or degradation evidence for material reassessment.
- Retrieve applicable product authorization and residue evidence before a veterinary-use decision.
- Identify handling and disposal controls from material-specific hazard and environmental evidence.
Hazards and failure modes required Filled
- Toxic to some dog breeds and to aquatic organisms.
- Overuse drives parasite resistance.
Standards and interfaces required Filled
- Regulation (EU) 2019/6, issued by the European Parliament and the Council of the European Union, governs veterinary medicinal products containing doramectin in the European Union.
- Commission Regulation (EU) No 37/2010, issued by the European Commission, lists doramectin within the framework for pharmacologically active substances and maximum residue limits in foodstuffs of animal origin.
Context of use required Filled
- Doramectin is encountered in veterinary medicines for controlling susceptible internal and external parasites in approved animal species.
- It is also encountered in pharmaceutical quality testing and residue monitoring associated with treated food-producing animals.
- Its suitability depends on the animal species, formulation, authorized indication and applicable veterinary requirements.
Sources Filled
- Wikidata item Q906534: doramectin - identity and sense of the item
- Wikipedia: Doramectin - general description of the item
Open questions
- Which stereochemically explicit reference structure reconciles differing database mappings, and is an EC identifier verified for that exact entity?
- Which recognized API specification and analytical methods establish doramectin assay, epimer discrimination and impurity acceptance limits?
- Which measured solid-form, solubility and thermal data are reliable, and is a boiling-point value meaningful before decomposition?
- Which bulk-material stability studies, GHS classifications and occupational exposure limits are applicable to the grade being assessed?
- Which current jurisdiction-specific authorizations, residue requirements, parasite-resistance data and environmental endpoints are needed for the intended use?
Machine files
Provenance
thing registry research (pass 2) · unreviewed
Built from: models/things/publications/thing-q906534/spec.json