neuroblastoma
Let an agent explain neuroblastoma in general terms from paediatric oncology guidelines, describe risk groups, treatment and outcomes, distinguish it from other childhood tumours, and route personal questions to clinicians.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain neuroblastoma in general terms from paediatric oncology guidelines, describe risk groups, treatment and outcomes, distinguish it from other childhood tumours, and route personal questions to clinicians.
A cancer of immature nerve cells of the sympathetic nervous system, the most common solid tumour outside the brain in children, arising most often in the adrenal glands and along the spine as adrenal or extracranial neuroblastoma, ranging from localized and regional disease that may regress or differentiate to high-risk metastatic and relapsed disease, with the intermediate ganglioneuroblastoma showing partial maturation; treatment depends on risk group and combines surgery, chemotherapy, radiotherapy, stem cell transplant and immunotherapy.
What it is for: Not applicable; a cancer.
It can be explain the disease and risk groups; relay treatment and outcomes; distinguish from other tumours; route personal questions.
Distinguishing features
Sympathetic nervous system origin
Early childhood
Risk-stratified treatment
Spontaneous regression in some infants
What it looks like
Not a visible object; a tumour in the adrenal gland or along the sympathetic chain.
Physical character
share of childhood cancers: about 6-8 percent
median age at diagnosis: about 18 months
high-risk five-year survival: about 50 percent - improving
How it is recognised
Childhood cancer of sympathetic nerve cells
Adrenal, extracranial, localized, regional, metastatic, relapsed and differentiating neuroblastoma; ganglioneuroblastoma
Wilms tumour is a kidney cancer; neuroblastoma is not a brain tumour despite the name
Related models
is a kind of - in registry terms
is a kind of - in registry terms
is a kind of - in registry terms, as a paediatric cancer
is stratified by - amplification and other markers
In practice
Families and kinds
adrenal neuroblastoma
extracranial neuroblastoma along the sympathetic chain
localized and regional neuroblastoma
metastatic and stage 4S neuroblastoma
relapsed neuroblastoma
differentiating neuroblastoma and ganglioneuroblastoma
MYCN-amplified high-risk disease
Identifiers
ICD-11 2A00.2 neuroblastoma
MeSH D009447 neuroblastoma
Standards and regulation
International Neuroblastoma Risk Group classification
Paediatric oncology protocols such as COG and SIOPEN
Cancer registration standards
Failure modes and hazards
Delayed diagnosis
Agents giving personal medical advice
Confusing neuroblastoma with brain tumours
Overgeneralising outcomes across risk groups
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Help Getting help first.
Safety.
Signs
Warning signs.
Signs
Signs.
- What signs in a child, such as an abdominal mass, bone pain or unexplained bruising around the eyes, need prompt assessment? action
- Is the user describing such signs in a child, which need a clinician promptly? boundary
Care
Specialist care.
Care
Care.
- How is neuroblastoma diagnosed and staged by paediatric oncology teams, in general terms? provenance
- Is the user asking about their own child diagnosis, which needs the oncology team? boundary
Understand The disease.
Clinical.
Disease
Disease and biology.
Disease
Disease.
- What is neuroblastoma, where does it arise, and why can it regress or mature? definition
- Is the question about neuroblastoma or another childhood tumour? boundary
Risk
Risk groups.
Risk
Risk.
- How are low, intermediate and high-risk groups defined by stage, age, MYCN and histology? provenance
- Which entry fits the specific risk group or stage? action
Treat Treatment.
Clinical.
Treatment
Treatment.
Treatment
Treatment.
- What treatments do protocols use for each risk group, in general terms? provenance
- Which references are standard? provenance
Outcomes
Outcomes and survivorship.
Outcomes
Outcomes.
- What outcomes are seen, and what late effects and follow-up exist for survivors? provenance
- Which sources are cited? provenance
Context Research and support.
Context.
Research
Research.
Research
Research.
- What research addresses immunotherapy, targeted therapy and relapsed disease, with findings attributed? provenance
- Which entry fits paediatric cancer research? action
Support
Support.
Support
Support.
- What organisations support families affected by neuroblastoma? provenance
- Which entry fits the specific organisation? action
What the second pass must settle
- Should ganglioneuroblastoma be a separate entry?
- How should paediatric oncology guidelines be linked?
- The registry entry has merged aliases naming stages and sites; should they be split off?