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Disease / Biological Condition

vr.wm-liv-021 · wm-liv-021-disease-biological-condition

Represent one governed biological condition occurrence concerning an organism plus immutable source-qualified assertions about its identity, course, evidence and relationships.

World Models Physical world and living systems PHY.LIV.HLT
Bundle → Layer → Finding → QuestionsClassifiersWhat it isWhy it existsDistinguishing featuresWhat robots and AI may and may not doMoral aspectsOwnersLinks to other meta-modelsIdentity and identifiersDirect propertiesRecognitionCapabilities and actionsHazards and failure modesStandards and interfacesContext of useSources

Bundle → Layer → Finding → Questions Filled

6 bundles · 12 layers · 24 findings · 72 questions

Condition identity, boundary and disease concept Groups the governed Resource Consumption concern for condition identity, boundary and disease concept.

Condition occurrence identity, subject and mastership

Groups Resource Consumption context for condition occurrence identity, subject and mastership without importing neighboring master lifecycles.

Condition identifier, subject kind, organism reference and master system

Records condition identifier, subject kind, organism reference and master system as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish condition identifier, subject kind, organism reference and master system? identity
  2. Which status, clocks, evidence, method, actor and clinical context qualify condition identifier, subject kind, organism reference and master system? authority
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect condition identifier, subject kind, organism reference and master system? security

Occurrence discriminator, episode boundary, alias, profile and record linkage

Records occurrence discriminator, episode boundary, alias, profile and record linkage as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish occurrence discriminator, episode boundary, alias, profile and record linkage? classification
  2. Which status, clocks, evidence, method, actor and clinical context qualify occurrence discriminator, episode boundary, alias, profile and record linkage? requirement
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect occurrence discriminator, episode boundary, alias, profile and record linkage? privacy

Disease concept, code, definition and classification

Groups Resource Consumption context for disease concept, code, definition and classification without importing neighboring master lifecycles.

Disease concept, code system, release, display, definition and synonym

Records disease concept, code system, release, display, definition and synonym as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish disease concept, code system, release, display, definition and synonym? classification
  2. Which status, clocks, evidence, method, actor and clinical context qualify disease concept, code system, release, display, definition and synonym? constraint
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect disease concept, code system, release, display, definition and synonym? retention

Category, hierarchy, postcoordination, rare-disease and species profile

Records category, hierarchy, postcoordination, rare-disease and species profile as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish category, hierarchy, postcoordination, rare-disease and species profile? interoperability
  2. Which status, clocks, evidence, method, actor and clinical context qualify category, hierarchy, postcoordination, rare-disease and species profile? process
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect category, hierarchy, postcoordination, rare-disease and species profile? access
Pathology, anatomy and direct properties Groups the governed Resource Consumption concern for pathology, anatomy and direct properties.

Pathological class, site, morphology and mechanism

Groups Resource Consumption context for pathological class, site, morphology and mechanism without importing neighboring master lifecycles.

Disorder, disease, syndrome, injury, infection, anomaly and finding profile

Records disorder, disease, syndrome, injury, infection, anomaly and finding profile as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish disorder, disease, syndrome, injury, infection, anomaly and finding profile? classification
  2. Which status, clocks, evidence, method, actor and clinical context qualify disorder, disease, syndrome, injury, infection, anomaly and finding profile? event
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect disorder, disease, syndrome, injury, infection, anomaly and finding profile? exception

Body site, laterality, morphology, pathological process, mechanism and extent

Records body site, laterality, morphology, pathological process, mechanism and extent as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish body site, laterality, morphology, pathological process, mechanism and extent? spatial
  2. Which status, clocks, evidence, method, actor and clinical context qualify body site, laterality, morphology, pathological process, mechanism and extent? measurement
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect body site, laterality, morphology, pathological process, mechanism and extent? interoperability

Intrinsic behavior, capability and distinguishing characteristics

Groups Resource Consumption context for intrinsic behavior, capability and distinguishing characteristics without importing neighboring master lifecycles.

Progression, persistence, transmission, damage, reversibility and instability

Records progression, persistence, transmission, damage, reversibility and instability as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish progression, persistence, transmission, damage, reversibility and instability? state
  2. Which status, clocks, evidence, method, actor and clinical context qualify progression, persistence, transmission, damage, reversibility and instability? evidence
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect progression, persistence, transmission, damage, reversibility and instability? decision

Recognition features, discriminators, confounders and condition affordances

Records recognition features, discriminators, confounders and condition affordances as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish recognition features, discriminators, confounders and condition affordances? evidence
  2. Which status, clocks, evidence, method, actor and clinical context qualify recognition features, discriminators, confounders and condition affordances? quality
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect recognition features, discriminators, confounders and condition affordances? identity
Independent status, time and clinical course Groups the governed Resource Consumption concern for independent status, time and clinical course.

Clinical, verification, record and assertion status

Groups Resource Consumption context for clinical, verification, record and assertion status without importing neighboring master lifecycles.

Clinical active, inactive, remission, relapse, recurrence, resolved and unknown

Records clinical active, inactive, remission, relapse, recurrence, resolved and unknown as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish clinical active, inactive, remission, relapse, recurrence, resolved and unknown? state
  2. Which status, clocks, evidence, method, actor and clinical context qualify clinical active, inactive, remission, relapse, recurrence, resolved and unknown? validation
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect clinical active, inactive, remission, relapse, recurrence, resolved and unknown? classification

Unconfirmed, provisional, differential, confirmed, refuted, excluded and record status

Records unconfirmed, provisional, differential, confirmed, refuted, excluded and record status as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish unconfirmed, provisional, differential, confirmed, refuted, excluded and record status? validation
  2. Which status, clocks, evidence, method, actor and clinical context qualify unconfirmed, provisional, differential, confirmed, refuted, excluded and record status? security
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect unconfirmed, provisional, differential, confirmed, refuted, excluded and record status? composition

Onset, manifestation, diagnosis and course clocks

Groups Resource Consumption context for onset, manifestation, diagnosis and course clocks without importing neighboring master lifecycles.

Onset, manifestation, recognition, diagnosis, recording and effective time

Records onset, manifestation, recognition, diagnosis, recording and effective time as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish onset, manifestation, recognition, diagnosis, recording and effective time? temporal
  2. Which status, clocks, evidence, method, actor and clinical context qualify onset, manifestation, recognition, diagnosis, recording and effective time? privacy
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect onset, manifestation, recognition, diagnosis, recording and effective time? relationship

Remission, relapse, recurrence, abatement, resolution, death and new occurrence

Records remission, relapse, recurrence, abatement, resolution, death and new occurrence as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish remission, relapse, recurrence, abatement, resolution, death and new occurrence? lifecycle
  2. Which status, clocks, evidence, method, actor and clinical context qualify remission, relapse, recurrence, abatement, resolution, death and new occurrence? retention
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect remission, relapse, recurrence, abatement, resolution, death and new occurrence? state
Severity, stage, grade, course and impact Groups the governed Resource Consumption concern for severity, stage, grade, course and impact.

Severity, stage, grade, extent and course assessment

Groups Resource Consumption context for severity, stage, grade, extent and course assessment without importing neighboring master lifecycles.

Severity value, scale, method, threshold, assessor, time and confidence

Records severity value, scale, method, threshold, assessor, time and confidence as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish severity value, scale, method, threshold, assessor, time and confidence? measurement
  2. Which status, clocks, evidence, method, actor and clinical context qualify severity value, scale, method, threshold, assessor, time and confidence? access
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect severity value, scale, method, threshold, assessor, time and confidence? lifecycle

Stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal

Records stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal? classification
  2. Which status, clocks, evidence, method, actor and clinical context qualify stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal? exception
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal? temporal

Functional impact, prognosis, hazard and possible actions

Groups Resource Consumption context for functional impact, prognosis, hazard and possible actions without importing neighboring master lifecycles.

Impairment, activity, participation, burden, quality of life and context

Records impairment, activity, participation, burden, quality of life and context as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish impairment, activity, participation, burden, quality of life and context? relationship
  2. Which status, clocks, evidence, method, actor and clinical context qualify impairment, activity, participation, burden, quality of life and context? interoperability
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect impairment, activity, participation, burden, quality of life and context? spatial

Prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent

Records prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent? decision
  2. Which status, clocks, evidence, method, actor and clinical context qualify prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent? decision
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent? provenance
Etiology, evidence, differential and related conditions Groups the governed Resource Consumption concern for etiology, evidence, differential and related conditions.

Cause, risk, susceptibility, trigger and association

Groups Resource Consumption context for cause, risk, susceptibility, trigger and association without importing neighboring master lifecycles.

Causative agent, mechanism, inheritance, gene, variant, pathogen and exposure

Records causative agent, mechanism, inheritance, gene, variant, pathogen and exposure as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish causative agent, mechanism, inheritance, gene, variant, pathogen and exposure? relationship
  2. Which status, clocks, evidence, method, actor and clinical context qualify causative agent, mechanism, inheritance, gene, variant, pathogen and exposure? identity
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect causative agent, mechanism, inheritance, gene, variant, pathogen and exposure? ownership

Risk factor, susceptibility, trigger, protective factor, association and causality

Records risk factor, susceptibility, trigger, protective factor, association and causality as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish risk factor, susceptibility, trigger, protective factor, association and causality? evidence
  2. Which status, clocks, evidence, method, actor and clinical context qualify risk factor, susceptibility, trigger, protective factor, association and causality? classification
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect risk factor, susceptibility, trigger, protective factor, association and causality? authority

Criteria, observation, phenotype, evidence and differential

Groups Resource Consumption context for criteria, observation, phenotype, evidence and differential without importing neighboring master lifecycles.

Diagnostic rule, case definition, observation, test, phenotype and evidence

Records diagnostic rule, case definition, observation, test, phenotype and evidence as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish diagnostic rule, case definition, observation, test, phenotype and evidence? validation
  2. Which status, clocks, evidence, method, actor and clinical context qualify diagnostic rule, case definition, observation, test, phenotype and evidence? composition
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect diagnostic rule, case definition, observation, test, phenotype and evidence? requirement

Differential, competing, alternative, refuted, excluded, uncertain and conflict

Records differential, competing, alternative, refuted, excluded, uncertain and conflict as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish differential, competing, alternative, refuted, excluded, uncertain and conflict? decision
  2. Which status, clocks, evidence, method, actor and clinical context qualify differential, competing, alternative, refuted, excluded, uncertain and conflict? relationship
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect differential, competing, alternative, refuted, excluded, uncertain and conflict? constraint
Relationships, governance, provenance and exchange Groups the governed Resource Consumption concern for relationships, governance, provenance and exchange.

Manifestation, complication, comorbidity, care and outcome links

Groups Resource Consumption context for manifestation, complication, comorbidity, care and outcome links without importing neighboring master lifecycles.

Sign, symptom, observation, phenotype, complication, comorbidity and sequela

Records sign, symptom, observation, phenotype, complication, comorbidity and sequela as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish sign, symptom, observation, phenotype, complication, comorbidity and sequela? relationship
  2. Which status, clocks, evidence, method, actor and clinical context qualify sign, symptom, observation, phenotype, complication, comorbidity and sequela? state
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect sign, symptom, observation, phenotype, complication, comorbidity and sequela? process

Encounter, care plan, intervention, medication, procedure, outcome and decision

Records encounter, care plan, intervention, medication, procedure, outcome and decision as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish encounter, care plan, intervention, medication, procedure, outcome and decision? relationship
  2. Which status, clocks, evidence, method, actor and clinical context qualify encounter, care plan, intervention, medication, procedure, outcome and decision? lifecycle
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect encounter, care plan, intervention, medication, procedure, outcome and decision? event

Provenance, lifecycle, access, quality and interoperability

Groups Resource Consumption context for provenance, lifecycle, access, quality and interoperability without importing neighboring master lifecycles.

Asserter, recorder, source, method, review, correction, merge, split and audit

Records asserter, recorder, source, method, review, correction, merge, split and audit as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish asserter, recorder, source, method, review, correction, merge, split and audit? provenance
  2. Which status, clocks, evidence, method, actor and clinical context qualify asserter, recorder, source, method, review, correction, merge, split and audit? temporal
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect asserter, recorder, source, method, review, correction, merge, split and audit? measurement

Sensitivity, consent, purpose, retention, quality and standards projection

Records sensitivity, consent, purpose, retention, quality and standards projection as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.

  1. Which condition identity, subject, disease concept, classification release and direct biological properties establish sensitivity, consent, purpose, retention, quality and standards projection? privacy
  2. Which status, clocks, evidence, method, actor and clinical context qualify sensitivity, consent, purpose, retention, quality and standards projection? spatial
  3. Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect sensitivity, consent, purpose, retention, quality and standards projection? evidence

Classifiers Filled

Family
World Models
Category
Physical world and living systems
Entry kind
aggregate
Navigation path
NAV.PHY.LIV.HLT
Domain
PHY.LIV.HLT
Industry
Cross-industry
Tags
diseasebiologicalconditionphy.liv.hlt

What it is Filled

Owns condition occurrence identity, subject reference, occurrence boundary and mastership; release-pinned disease concept bindings; pathological class, site, morphology, mechanism and direct behavior; independent clinical, verification and record statuses; onset, manifestation, recognition, diagnosis, recording, remission, relapse, recurrence and resolution clocks; severity, stage, grade, course, functional impact and prognosis assertions; etiology, risk, susceptibility, triggers, criteria, evidence and differential relationships; manifestation, complication, comorbidity, sequela, care and outcome links; provenance, quality, lifecycle, access, retention and loss-aware projections. Disease terminology, organisms, people, specimens, encounters, care plans, observations, tests, phenotypes, genes, variants, pathogens, interventions, outcomes, evidence documents and decisions remain external.

In scope

  • Condition occurrence identity, subject, disease concept bindings and direct pathological properties
  • Independent statuses, course clocks, severity, stage, etiology, evidence, differential and related-condition assertions
  • Provenance, quality, correction, access, retention and loss-aware interoperability

Out of scope

  • Owning disease terminology, organism, person, specimen, encounter, care plan, observation, test, phenotype, gene, variant, pathogen, intervention, outcome, evidence-document or decision lifecycles
  • Inferring diagnosis, causation, cure, prognosis, treatment or public-health case status without source-qualified authority and evidence
  • Protected disclosure, clinical decision, external-system mutation, identity merge or irreversible deletion without authority

Why it exists Filled

Represent one governed biological condition occurrence concerning an organism plus immutable source-qualified assertions about its identity, course, evidence and relationships.

Distinguishing features Filled

  • Represents one condition occurrence in one organism, not the disease concept in a terminology.
  • Clinical status, verification status and record status are independent axes.
  • Remission is not cure, susceptibility is not disease, and association is not causation.
  • A diagnosis is an authority-qualified assertion; a single observation or test result is not a diagnosis.

What robots and AI may and may not do Filled

Must not

  • Make or confirm a diagnosis.
  • Infer a condition from one observation or from genetic susceptibility.
  • Disclose a condition outside the authorised purpose.
  • Merge or delete condition records without authority.
  • Report a public-health case without the responsible authority.

Only with a human decision

  • Diagnosis and verification of a condition.
  • Disclosure of a condition to third parties.
  • Notification to public-health authorities.

May

  • Record a condition with a release-pinned terminology code and source.
  • Validate codes against the declared terminology release.
  • Detect probable duplicate condition records for review.
  • Summarise the course, stage and severity history from recorded assertions.

Moral aspects Filled

  • Health conditions are sensitive data; disclosure can cause stigma, discrimination and loss of work or insurance.
  • Wrong or outdated diagnoses can lead to harmful treatment.
  • Public-health reporting must balance community protection against individual privacy.
  • Animal conditions also matter for welfare and for diseases shared with people.

Who is affected

  • Patients
  • Animals and their keepers
  • Clinicians and veterinarians
  • Communities affected by public-health decisions

Owners Filled

Steward

Declare Dimension owner, condition and organism masters, terminology stewards, diagnostic authorities, data stewards, access approvers and auditors.

Roles

Dimension owner
Own namespace, mastership, delegation, access, retention and federation rules.
Condition registry steward
Own occurrence identity, deduplication, lifecycle, quality and terminology bindings.
Terminology authority or curator
Own concept systems, releases, definitions, mappings and classification profiles.
Clinical or biological asserter
Own diagnosis, clinical status, severity, stage, course and evidence assertions within delegated scope.
Laboratory or observation steward
Own specimen, test, observation, phenotype and source evidence outside this model.
Care or public-health authority
Own care-plan, encounter, surveillance, reporting and intervention decisions outside this model.
Data steward or access authority
Own consent, purpose, sensitivity, minimum disclosure, retention and access decisions.
Reviewer or auditor
Review identity, evidence, conflicts, lifecycle, quality and disclosure without rewriting originals.

Links to other meta-models Filled

references

  • WM-LIV-002 Organism Individual - Resolve the registered organism subject without importing its identity or lifecycle.
  • WM-ACT-049 Care Plan / Episode - Resolve care context, goals and interventions while condition and care-plan mastership remain separate.
  • Specimen, observation, test, phenotype, evidence, intervention, outcome and decision masters - Resolve diagnostic and care context without importing neighboring lifecycles.

aligned

  • WHO ICD-11 2026 release and ICF - Project disease classification, coding and functioning context with exact releases and explicit scope.
  • SNOMED CT clinical finding and disorder model - Project disorder, finding site, morphology, cause, severity, course and occurrence attributes under licensed release pins.
  • HL7 FHIR R5 Condition, ClinicalImpression and Observation - Project clinical exchange views while preserving resource maturity, status axes and diagnostic boundaries.
  • OMOP CDM 5.4 ConditionOccurrence and ConditionEra - Project observational analytics records and era derivation without treating analytics rules as biological truth.
  • Mondo, Human Disease Ontology, Orphanet and NCI Thesaurus - Project disease concepts, definitions, mappings, rare-disease and cancer terminology with exact releases.
  • Human Phenotype Ontology and GA4GH Phenopacket Schema - Project phenotypic evidence and disease diagnoses while keeping observed features distinct.
  • ClinGen Gene-Disease Validity and CDC surveillance case definitions - Project evidence-based relationship strength and jurisdictional case classification as separate assertions.
  • W3C PROV-O, DQV and ODRL 2.2 - Project derivation, quality, rights and access constraints.
  • RFC 3339 and RFC 8785 - Project unambiguous clocks and deterministic JSON serialization.

neighbor

  • WM-LIV-002 Organism Individual - The registered parent is retained as the subject reference. The organism owns biological identity and lifecycle; this model owns only the condition occurrence and its assertions.
  • Disease concept and classification - ICD, SNOMED CT, Mondo, Disease Ontology, Orphanet and NCI terminology concepts define categories and mappings. They are not the real condition occurrence affecting one organism.
  • Diagnosis and clinical impression - A diagnosis is an attributable epistemic assertion with verification state, criteria, evidence and uncertainty. It can be revised without rewriting the underlying condition occurrence.
  • Observation, phenotype and specimen - Signs, symptoms, measurements, tests and phenotypic abnormalities are evidence or manifestations linked to a condition. Their subjects, methods, values and lifecycle remain external.
  • WM-ACT-049 Care Plan / Episode - A care plan or episode may target a condition, but encounters, goals, interventions, medications, procedures and care outcomes keep independent mastership.
  • Public-health surveillance case - A surveillance case applies jurisdictional criteria for counting and reporting and is explicitly not a substitute for individual clinical diagnosis.
  • Cause, prognosis and outcome - Causal attribution and prognosis are qualified assertions; actual outcomes are external events or states. Association, susceptibility, prediction and outcome are never silently treated as intrinsic disease truth.

parent

  • WM-LIV-002

What else AI and robots need to interact with it Filled

Identity and identifiers required Filled

  • Authoritative master-system identifier for the condition occurrence or source clinical record.
  • Terminology-qualified immutable identifier for a diagnostic, status, evidence or lifecycle assertion.
  • Adopting-Dimension UUID or ULID when no authoritative external identifier exists.

Direct properties not applicable Not applicable

Not applicable

A condition is a clinical concept; severity and stage are assessments recorded about a person, not physical properties.

Recognition required Filled

  • A condition record has a subject, a coded concept, clinical and verification status, onset and the asserting authority.
  • Often confused with a disease concept, an observation, a symptom and a diagnostic test result.

Capabilities and actions required Filled

  • Register condition occurrence: Create stable occurrence identity for one condition concerning one organism while preserving source record links.
  • Bind disease concept: Attach a release-pinned disease concept without making the terminology entry the occurrence identity.
  • Assert diagnosis or hypothesis: Append a source-qualified diagnostic assertion with independent verification status and evidence.
  • Record independent status: Record clinical activity, verification and record state as separate controlled assertions.
  • Record course, stage and severity: Append time-bound course, stage, grade, severity and extent assessments with method and scale.
  • Link cause, risk and evidence: Add typed causal, risk, susceptibility and evidentiary relationships without promoting association to causation.
  • Link manifestations and impact: Reference signs, symptoms, observations, phenotypes, complications and functioning effects.
  • Reconcile differential and duplicate: Compare competing diagnoses and duplicate records while preserving every original assertion and decision basis.
  • Govern condition lifecycle: Append correction, recurrence, relapse, remission, resolution, split, merge or supersession events.
  • Project authorized view: Produce a minimum-necessary standards projection with purpose, access and semantic-loss controls.

Hazards and failure modes required Filled

  • Misdiagnosis carried forward in records.
  • Disclosure of sensitive conditions.
  • Duplicate or conflicting records for one condition.
  • Missed or delayed notification of a notifiable disease.

Standards and interfaces required Filled

  • HL7 FHIR Condition.
  • WHO ICD-11.
  • SNOMED CT.
  • Mondo Disease Ontology.
  • Human Phenotype Ontology for manifestations.

Context of use required Filled

  • Human clinical terminology does not govern every species, research use, public-health regime or jurisdiction.
  • FHIR Condition and ClinicalImpression are Trial Use and living terminologies require exact maturity and release pins.
  • Diagnosis, notification, consent, privacy, retention, access and reporting duties vary by jurisdiction and organizational policy.

Sources Filled

  1. International Classification of Diseases - World Health Organization
  2. ICD API Documentation - World Health Organization
  3. ICD API Supported Classifications - World Health Organization
  4. ICD-11 Reference Guide - World Health Organization
  5. International Classification of Functioning, Disability and Health - World Health Organization
  6. Clinical finding and disorder - SNOMED International
  7. SNOMED CT Concept Model - SNOMED International
  8. FHIR R5 Condition - Health Level Seven International
  9. FHIR R5 ClinicalImpression - Health Level Seven International
  10. FHIR R5 Observation - Health Level Seven International
  11. OMOP Common Data Model 5.4 - Observational Health Data Sciences and Informatics
  12. Mondo Disease Ontology - Monarch Initiative
  13. Human Disease Ontology - Disease Ontology Project
  14. Orphanet Classifications - Orphanet
  15. Human Phenotype Ontology - Monarch Initiative
  16. Phenopacket Schema Disease - Global Alliance for Genomics and Health
  17. Gene-Disease Validity Classification - Clinical Genome Resource
  18. Surveillance Case Definitions - Centers for Disease Control and Prevention
  19. NCI Thesaurus - National Cancer Institute
  20. PROV-O: The PROV Ontology - World Wide Web Consortium
  21. Data Quality Vocabulary - World Wide Web Consortium
  22. ODRL Information Model 2.2 - World Wide Web Consortium
  23. Date and Time on the Internet - Internet Engineering Task Force
  24. JSON Canonicalization Scheme - Internet Engineering Task Force

Open questions

  • Develop disease-family and species-specific diagnostic, staging, severity, course, treatment, surveillance and safety profiles with domain experts.
  • Resolve detailed sibling boundaries for organism, specimen, observation, phenotype, encounter, care plan, intervention, outcome, evidence, prediction and decision models.
  • Pin production crosswalks to exact ICD, SNOMED CT, FHIR, OMOP, Mondo, Disease Ontology, Orphanet, HPO, Phenopacket and NCI releases and execute conformance suites.
  • Obtain independent clinical, biological, veterinary, terminology, epidemiology, privacy, legal, security and records review.
  • Disease-specific diagnostic, staging, severity, treatment, surveillance, species, jurisdictional and safety profiles require expert review.
  • Organisms, people, specimens, encounters, care plans, observations, tests, phenotypes, causes, interventions, outcomes, terminologies, evidence and decisions remain neighboring masters.
  • Automated diagnosis, prognosis, treatment selection, surveillance reporting and unrestricted protected-health disclosure remain outside scope.

Machine files

Card as JSON Specification AGENTS.md Source Card backlog vercy.card/1

Provenance

world-models research · reviewable-draft

Built from: models/wm-liv-021-disease-biological-condition/spec.yaml, ver-cy/world-models/card-supplements/wm-liv-021-disease-biological-condition.json