CTSG
Let an agent explain the CTSG gene and its product cathepsin G, relay function, location and disease associations from curated genomic sources, and keep the gene apart from its protein, from the cysteine cathepsins and from other neutrophil proteases.
Bundle → Layer → Finding → Questions Filled
4 bundles · 8 layers · 8 findings · 16 questions
Gene identity Symbol, name and location.
Nomenclature
Symbol and aliases.
Nomenclature
Symbol and aliases.
- What is the official symbol and name, and which aliases are in use? definition
- Which database holds the authoritative record? provenance
Locus
Chromosomal location.
Locus
Chromosomal location.
- Where on chromosome 14 does CTSG lie, and which genes neighbour it? provenance
- Which genome assembly is the location given against? measurement
Protein Cathepsin G.
Enzyme class
Serine protease.
Enzyme class
Serine protease.
- What class of enzyme is cathepsin G, and how does it differ from cysteine cathepsins? boundary
- Which substrates does it act on? provenance
Expression
Where it is made and stored.
Expression
Where it is made and stored.
- In which cells is it expressed, and where is it stored? provenance
- When is it released? definition
Function Role in immunity and inflammation.
Host defence
Killing microbes.
Host defence
Killing microbes.
- How does cathepsin G contribute to killing engulfed microbes? provenance
- Which evidence supports this role? provenance
Inflammation
Tissue effects.
Inflammation
Tissue effects.
- How does it affect tissue and signalling at sites of inflammation? provenance
- Which effects are shown in humans and which in models? boundary
Associations Disease and research links.
Disease links
Reported associations.
Disease links
Reported associations.
- Which diseases have been linked to CTSG or cathepsin G, and how strong is the evidence? provenance
- Is the link to the gene, the protein level or autoantibodies? boundary
Variants
Genetic variation.
Variants
Genetic variation.
- Are any CTSG variants classified in curated clinical databases? provenance
- Who may interpret a variant found in a patient? action
Classifiers Filled
- Family
- Thing Registry
- Category
- Physical world and living systems
- Entry kind
- thing
- Plane
- PHY
- Domain
- PHY.LIV
What it is Filled
CTSG is the human protein-coding gene for cathepsin G, a serine protease stored in the azurophilic granules of neutrophils that is released at sites of inflammation and helps kill engulfed microbes and remodel tissue; the gene lies in a cluster of related protease genes on chromosome 14.
Why it exists Filled
Let an agent explain the CTSG gene and its product cathepsin G, relay function, location and disease associations from curated genomic sources, and keep the gene apart from its protein, from the cysteine cathepsins and from other neutrophil proteases.
Distinguishing features Filled
- A serine protease, unlike most cathepsins, which are cysteine proteases
- The gene is not the protein: CTSG names the gene, cathepsin G the enzyme
- Distinct from neutrophil elastase (ELANE) and proteinase 3 (PRTN3), other granule serine proteases
- Human gene, distinct from its orthologues in other species
What robots and AI may and may not do Filled
Must not
- Interpret a person's genetic test result as a diagnosis.
- Disclose or infer a named person's genetic data without consent.
- State a variant is disease-causing without a curated classification.
Only with a human decision
- Clinical interpretation of a variant found in a patient.
- Any genetic counselling decision.
May
- Relay the gene's function and associations from curated databases and cite them.
- Explain the difference between the gene, its protein and a variant.
Moral aspects Filled
- Genetic data is sensitive and identifying.
- Overstated associations can mislead patients and research.
Who is affected
- People who have their genes tested
- Their relatives
- Researchers
Owners Filled
Steward
Nobody owns the gene; the gene nomenclature authority maintains its official name and symbol.
Master systems
- HGNC
- NCBI Gene
- Ensembl
- UniProt
Links to other meta-models Filled
parent
- Q20747295 - registry parent class
related
- protein-coding gene
- cysteine cathepsins - share the cathepsin name but differ in mechanism
- ELANE - another neutrophil serine protease gene
- cathepsin G (protein) - the product, not the gene
What else AI and robots need to interact with it Filled
Identity and identifiers required Filled
- Vercy registry: vr.tr.ctsg
- Wikidata: Q14906548 (https://www.wikidata.org/wiki/Q14906548)
- Wikidata: Q14906548 registry item
- HGNC symbol: CTSG official human gene symbol
- HGNC ID: HGNC: followed by digits look up in the HGNC database
- NCBI Gene ID: digits only look up in NCBI Gene
Direct properties required Filled
- kind: protein-coding gene note
- organism: Homo sapiens note
- product: cathepsin G, a serine protease note
Recognition required Filled
- Official HGNC symbol CTSG in human gene records
- Protein named cathepsin G
- Located on chromosome 14 near the granzyme gene cluster
Capabilities and actions required Filled
- identify the gene and its official symbol
- relay the function of the encoded protein
- relate it to neighbouring protease genes
- relay curated disease and research associations
- point to authoritative gene records
Hazards and failure modes required Filled
- Confusing the gene with the protein or with cysteine cathepsins
- Overstating disease associations from single studies
- Misusing personal genetic data
Standards and interfaces required Filled
- HGNC gene nomenclature rules
- Genetic data protection under health and privacy law
Context of use required Filled
- Encoding cathepsin G, which takes part in the immune defence and inflammatory functions of neutrophils.
- chymotrypsin-like serine protease family
- neutrophil granule serine proteases
- orthologues in other mammals
Sources Filled
- Wikidata item Q14906548: CTSG - identity and sense of the item
- Wikipedia: Cathepsin G - general description of the item
Open questions
- How strong are the reported disease associations?
- Should the protein have its own linked entry?
- How should orthologues in other species be linked?
Machine files
Provenance
thing registry research (pass 2) · unreviewed
Built from: models/things/publications/thing-q14906548/spec.json