cell adhesion
Let an agent explain cell adhesion and its molecular basis, relay adhesion molecule families, mechanisms and roles in development and disease from cell biology sources, describe the Gene Ontology sub-processes the registry aliases name, and distinguish cell adhesion from cell junctions as structures, from cell migration and from aggregation of non-living particles.
Bundle → Layer → Finding → Questions Filled
4 bundles · 8 layers · 8 findings · 16 questions
Understand What cell adhesion is.
Definition
Definition.
Definition
Definition.
- What is cell adhesion, and how does it differ from junctions, migration and particle aggregation? definition
- Is the question about molecules, mechanisms, development, disease or ontology terms? boundary
Kinds
Kinds.
Kinds
Kinds.
- What are cell-cell, cell-substrate and integrin-mediated adhesion, and the developmental sub-processes named in the Gene Ontology? definition
- Which entry fits the specific kind? action
Molecules Molecules and mechanisms.
Families
Molecule families.
Families
Families.
- How do cadherins, integrins, selectins and Ig superfamily molecules bind? provenance
- Which references are standard? provenance
Signalling
Signalling.
Signalling
Signalling.
- How does adhesion signal into the cell and connect to the cytoskeleton? provenance
- Which sources are cited? provenance
Biology Development and disease.
Development
Development.
Development
Development.
- How does adhesion drive morphogenesis, such as heart formation and prostatic bud elongation? provenance
- Which entry fits morphogenesis? action
Disease
Disease.
Disease
Disease.
- How do adhesion changes contribute to metastasis, inflammation and genetic disorders? provenance
- Which entry fits metastasis? action
Context Methods and history.
Methods
Methods.
Methods
Methods.
- How is cell adhesion measured in the laboratory? provenance
- Which entry fits cell adhesion assay? action
History
History.
History
History.
- How did Holtfreter, Steinberg and later molecular work establish the field? provenance
- Which entry fits the history of cell biology? action
Classifiers Filled
- Family
- Thing Registry
- Category
- Activities and processes
- Entry kind
- thing
- Plane
- ACT
- Domain
- ACT.PRC
- Other names and narrower kinds
- cell adhesion involved in prostatic bud elongation, cell-substrate adhesion, cell adhesion mediated by integrin, cell adhesion involved in heart morphogenesis, cell-cell adhesion, cell adhesion involved in retrograde extension, cell adhesion involved in sprouting angiogenesis, bacterial adhesion
What it is Filled
The process by which cells attach to each other or to the extracellular matrix through adhesion molecules such as cadherins, integrins, selectins and immunoglobulin superfamily proteins, comprising cell-cell adhesion and cell-substrate adhesion, including integrin-mediated adhesion, and contributing to development in processes such as heart morphogenesis, prostatic bud elongation and retrograde extension of neurons, as annotated in the Gene Ontology; cell adhesion underlies tissue structure, immunity, wound healing and cancer metastasis.
Why it exists Filled
Let an agent explain cell adhesion and its molecular basis, relay adhesion molecule families, mechanisms and roles in development and disease from cell biology sources, describe the Gene Ontology sub-processes the registry aliases name, and distinguish cell adhesion from cell junctions as structures, from cell migration and from aggregation of non-living particles.
Distinguishing features Filled
- Adhesion molecules
- Cell-cell and cell-matrix
- Developmental roles
- Disease relevance
What robots and AI may and may not do Filled
Must not
- Present laboratory findings as proven treatments for people.
- Misstate or fabricate experimental data on adhesion molecules.
- Promote unapproved therapies based on adhesion research.
Only with a human decision
- Using research results to make clinical decisions.
May
- Explain cell adhesion and its main molecule families in general terms, citing sources.
- Summarise research on adhesion in disease, such as cancer spread, with references.
Moral aspects Filled
- Research on adhesion feeds cancer and immune treatments; overstated findings raise false hope.
- Animal and human tissue research needs proper consent and oversight.
Who is affected
- Patients
- Researchers
- Research animals
Owners Filled
Steward
Nobody owns the process; the scientific community studies it.
Links to other meta-models Filled
parent
- Q14873025 - registry parent class
related
- cellular process or phenomenon - in registry terms
- cell adhesion molecule - such as cadherins and integrins
- cell junction - as structures
- Gene Ontology - as GO:0007155
What else AI and robots need to interact with it Filled
Identity and identifiers required Filled
- Vercy registry: vr.tr.cell-adhesion
- Wikidata: Q187640 (https://www.wikidata.org/wiki/Q187640)
- GO: GO:0007155 cell adhesion
- MeSH: D002448 Cell Adhesion
Direct properties not applicable Not applicable
- major molecule families: cadherins, integrins, selectins, Ig superfamily list
- Gene Ontology term: GO:0007155 note - cell adhesion
- integrin heterodimers, human: 24 count
Plane ACT: no invented physical properties.
Recognition optional Filled
- Attachment of cells to cells or matrix
- Cell-cell adhesion, cell-substrate adhesion, integrin-mediated adhesion, adhesion in heart morphogenesis and prostatic bud elongation
- Junctions are the structures; migration is movement; particle aggregation is non-living
- Not a visible object; cells attached to each other or to a matrix.
Capabilities and actions required Filled
- explain the process
- relay molecular mechanisms
- describe developmental roles
- distinguish related concepts
Hazards and failure modes required Filled
- Confusing adhesion with junction structures
- Registry aliases naming narrow GO sub-terms
- Overgeneralising from one molecule family
Standards and interfaces required Filled
- Gene Ontology annotation standards
Context of use required Filled
- Not applicable; a cellular process.
- cell-cell adhesion via cadherins and others
- cell-substrate adhesion via integrins
- selectin-mediated leukocyte adhesion
- adhesion in morphogenesis such as heart and prostate development
- adhesion in neuronal extension
- adhesion in cancer and immunity
Sources Filled
- Wikidata item Q187640: cell adhesion - identity and sense of the item
- Wikipedia: Cell adhesion - general description of the item
Open questions
- Should cell-cell and cell-substrate adhesion be separate primary entries?
- How should cell biology sources be linked?
- The registry entry has merged aliases naming specific GO sub-processes; should they be grouped?
Machine files
Provenance
thing registry research (pass 2) · unreviewed
Built from: models/things/publications/thing-q187640/spec.json