cell migration
Let an agent explain cell migration and its modes, relay mechanisms and roles in development, immunity, healing and disease from cell biology sources, and route clinical questions about cancer spread to clinicians.
Bundle → Layer → Finding → Questions Filled
4 bundles · 8 layers · 8 findings · 16 questions
Mechanism How cells move.
Machinery
Cytoskeleton and adhesion.
Machinery
Machinery.
- How do the cytoskeleton, adhesions and membrane protrusions move a cell? definition
- Is the question about active migration or passive transport? boundary
Guidance
Guidance cues.
Guidance
Guidance.
- How do chemical gradients, stiffness and other cues direct migration? provenance
- Which entry fits chemotaxis? action
Modes Kinds of migration.
Single
Single-cell modes.
Single
Single.
- How do amoeboid and mesenchymal migration differ? definition
- Which entry fits a specific cell type? action
Collective
Collective migration.
Collective
Collective.
- How do groups of cells migrate together in development and healing? provenance
- Which references are standard? provenance
Roles Roles in biology and disease.
Normal
Development, immunity, healing.
Normal
Normal.
- What roles does migration play in development, immune responses and wound healing? provenance
- Which entry fits wound healing? action
Disease
Disease.
Disease
Disease.
- How does migration contribute to metastasis and developmental disorders, in general terms? provenance
- Is the user asking about their own diagnosis, which needs a clinician? boundary
Study Methods and teaching.
Methods
Methods.
Methods
Methods.
- How is migration studied, from live imaging to migration assays and modelling? provenance
- How is migration measured? measurement
Teach
Teaching.
Teach
Teaching.
- How is cell migration taught in cell biology? action
- Which misconceptions arise? provenance
Classifiers Filled
- Family
- Thing Registry
- Category
- Activities and processes
- Entry kind
- thing
- Plane
- ACT
- Domain
- ACT.PRC
- Other names and narrower kinds
- leukocyte migration, germ cell migration, migracytosis, neuron migration, glial cell migration, ameboidal-type cell migration, muscle cell migration, wound healing, spreading of cells, skeletal muscle satellite cell migration, cell migration involved in heart development, forebrain cell migration, hypothalamus cell migration
What it is Filled
The directed movement of cells from one place to another, essential to embryonic development, immune responses, wound healing and tissue maintenance, and involved in cancer spread; cells migrate by crawling on surfaces or through tissues using the cytoskeleton, adhesion and signalling cues, in modes such as amoeboid, mesenchymal and collective migration.
Why it exists Filled
Let an agent explain cell migration and its modes, relay mechanisms and roles in development, immunity, healing and disease from cell biology sources, and route clinical questions about cancer spread to clinicians.
Distinguishing features Filled
- Active, directed cell movement
- Driven by cytoskeleton and adhesion
- Guided by chemical and physical cues
- Central to development, immunity and metastasis
What robots and AI may and may not do Filled
Must not
- Present laboratory findings as treatments for cancer.
- Promote unproven therapies claimed to stop cancer spread.
- Give a person a prognosis based on cell migration research.
Only with a human decision
- Use of human cells or tissue in research.
May
- Explain cell migration in development, immunity, wound healing and cancer spread.
- Report research findings with their limits.
Moral aspects Filled
- Cancer patients are vulnerable to overstated claims.
- Human cells come from donors who must consent.
Who is affected
- Cancer patients
- Tissue donors
- Researchers
Owners Filled
Steward
Nobody owns the process; it belongs to biology.
Links to other meta-models Filled
parent
- Q14873676 - registry parent class
related
- cell motility - the general category
- morphogenesis - a developmental role
- immune system - leukocyte trafficking
- metastasis - cancer cell spread
What else AI and robots need to interact with it Filled
Identity and identifiers required Filled
- Vercy registry: vr.tr.cell-migration
- Wikidata: Q189092 (https://www.wikidata.org/wiki/Q189092)
- Gene Ontology: GO:0016477 cell migration
Direct properties not applicable Not applicable
- speed: about 0.1-20 micrometres per minute - immune cells fastest
Plane ACT: no invented physical properties.
Recognition optional Filled
- Cells moving directionally
- Modes: amoeboid, mesenchymal, collective
- Passive transport in blood and cell division are different processes
- Not visible to the eye; under the microscope cells extending protrusions and crawling.
Capabilities and actions required Filled
- explain mechanisms and modes
- describe roles in development, immunity and healing
- explain involvement in cancer metastasis in general terms
- relay methods used to study migration
Hazards and failure modes required Filled
- Metastasis when cancer cells migrate
- Developmental disorders from failed migration
- Agents giving clinical advice
Standards and interfaces required Filled
- Gene Ontology definitions
- Research ethics rules for animal and human tissue studies
Context of use required Filled
- Moving cells to where they are needed in development, defence and repair.
- leukocyte migration
- neuronal and glial migration in the developing brain
- germ cell migration
- collective migration of cell sheets
- amoeboid and mesenchymal single-cell migration
- cancer cell invasion
Sources Filled
- Wikidata item Q189092: cell migration - identity and sense of the item
- Wikipedia: Cell migration - general description of the item
Open questions
- Should each migration mode be a separate entry?
- How should Gene Ontology terms be linked?
- The registry entry has merged aliases for specific cell types; should they be split off?
Machine files
Provenance
thing registry research (pass 2) · unreviewed
Built from: models/things/publications/thing-q189092/spec.json