immune disorder

Immune dysfunction boundary

Record the basis for treating an immune phenomenon as a disorder rather than a physiological response or isolated result.

1. What pathological change in immune function defines the proposed disorder? definition
2. What evidence distinguishes it from a normal response, transient variation or incidental laboratory abnormality? boundary

Supported subtype

Record the narrowest justified classification and its relationship to neighbouring immune disorders.

1. Which named disorder or family is supported, and which defining features justify that specificity? definition
2. Does the presentation combine deficiency, autoimmunity, hypersensitivity or other dysregulation, and how does the chosen classification represent that overlap? boundary

Component and function evidence

Connect implicated immune components to demonstrable functional changes.

1. Which immune cells, molecules or pathways are implicated, and what function is deficient, excessive or misdirected? definition
2. Which functional tests or other observations support that mechanism, and which parts remain hypothetical? provenance

Aetiological evidence

Represent inherited and acquired explanations without inferring origin from age at presentation alone.

1. What evidence supports an inherited, acquired or multifactorial origin, and who made that attribution? provenance
2. Are linked exposures, medicines, infections or genetic findings established causes, predispositions, triggers or unresolved associations? boundary

Versioned diagnostic basis

Record the applicable criteria, their intended use and the precision of terminology mappings.

1. Which issuing body's criteria and version support the assertion, and are they diagnostic criteria or classification criteria for another purpose? provenance
2. Which verified ICD and SNOMED CT concepts map to this category or subtype, in which releases, and with what degree of equivalence? boundary

Interpretable immune results

Require sufficient measurement context to judge immune abnormalities and discordant results.

1. What assay, units, reference interval, specimen and collection date accompany each result, and are age or treatment relevant to interpretation? measurement
2. What condition-specific evidence is needed to resolve transient, conflicting or clinically unexplained results? action

Longitudinal immune state

Use condition-appropriate definitions for active disease, stable dysfunction, relapse and remission.

1. What evidence establishes onset and a persistent, episodic or resolving course? measurement
2. Which activity or remission definitions apply to this subtype, and how do they distinguish improvement from lasting immune impairment? definition

Attributable burden

Record manifestation burden and epidemiological evidence without conflating association with causation.

1. Which infections, inflammatory manifestations or organ impairments are attributed to the disorder, and what supports each attribution? provenance
2. For each frequency estimate, what subtype, case definition, population, geography and observation year were studied? measurement

Monitoring and escalation basis

Connect monitoring and escalation decisions to documented guidance and the relevant immune phenotype.

1. Which changes in infection pattern, immune measurements or organ manifestations require reassessment under the applicable guidance? action
2. Which authority specifies monitoring intervals and escalation criteria, and for which subtype and population? provenance

Immune-specific action constraints

Record how the established immune phenotype affects consideration of treatment, vaccination or preventive measures.

1. What subtype-specific evidence and clinical review are required before considering immune-directed treatment, vaccination or infection prevention? action
2. Which documented immune deficits, current infections or treatment effects alter eligibility or require specialist review? boundary

Check these first

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these check these first hold for the sense of immune disorder this model covers, and on what evidence? provenance

Kinds and varieties

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these kinds and varieties hold for the sense of immune disorder this model covers, and on what evidence? provenance

Identifiers and schemes

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these identifiers and schemes hold for the sense of immune disorder this model covers, and on what evidence? provenance

Standards and regulation

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these standards and regulation hold for the sense of immune disorder this model covers, and on what evidence? provenance

Real-world use

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these real-world use hold for the sense of immune disorder this model covers, and on what evidence? provenance

Typical measurements

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these typical measurements hold for the sense of immune disorder this model covers, and on what evidence? provenance

Failure modes and hazards

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these failure modes and hazards hold for the sense of immune disorder this model covers, and on what evidence? provenance

Regional variation

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these regional variation hold for the sense of immune disorder this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these neighbouring kinds and how to tell them apart hold for the sense of immune disorder this model covers, and on what evidence? provenance