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quinolizidine alkaloid

vr.tr.quinolizidine-alkaloid · thing-q76515995

Let an agent describe quinolizidine alkaloids, their sources, structures and toxicity in general terms, and point to food safety guidance, without giving medical advice.

Thing Registry Physical world and living systems PHY.MAT
Bundle → Layer → Finding → QuestionsClassifiersWhat it isWhy it existsDistinguishing featuresWhat robots and AI may and may not doMoral aspectsOwnersLinks to other meta-modelsIdentity and identifiersDirect propertiesRecognitionCapabilities and actionsHazards and failure modesStandards and interfacesContext of useSources

Bundle → Layer → Finding → Questions Filled

4 bundles · 8 layers · 8 findings · 16 questions

Compound Which alkaloid.

Identity

Name and identifiers.

Compound

Name and IDs.

  1. Which compound? provenance
  2. What are its identifiers? provenance

Structure

Skeleton type.

Structure

Type.

  1. Which structural type? provenance
  2. How many rings? measurement
Occurrence Sources.

Plants

Species.

Plant source

Species and part.

  1. Which plants contain it? provenance
  2. At what levels? measurement

Foods

Lupin products.

Food content

Measured alkaloids, method, units, fresh weight or dry matter, and the survey or source.

  1. What levels occur in foods? measurement
  2. From which survey? provenance
Toxicology Effects.

Effects

Mechanism.

Toxic effect

Effect and source.

  1. What effects are reported? provenance
  2. At what exposure? measurement

Guidance

Limits.

Guidance value

Value and body.

  1. Which guidance values exist? provenance
  2. From which assessment? provenance
Uses Pharmacology.

Medicines

Approved uses.

Medicine

Compound and approval.

  1. Which compounds are medicines? provenance
  2. Where approved? provenance

Agriculture

Breeding.

Breeding

Varieties.

  1. How are low-alkaloid varieties bred? provenance
  2. Which varieties? provenance

Classifiers Filled

Family
Thing Registry
Category
Physical world and living systems
Entry kind
thing
Plane
PHY
Domain
PHY.MAT
Other names and narrower kinds
11-[(16-Hydroxy-5,7,11,19-tetraoxapentacyclo[10.8.0.02,10.04,8.013,18]icosa-2,4(8),9,13(18),14,16-hexaen-17-yl)methyl]-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one, 11-[(16-Hydroxy-5,7,11,19-tetraoxapentacyclo[10.8.0.02,10.04,8.013,18]icosa-2,4(8),9,13(18),14,16-hexaen-15-yl)methyl]-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one, Feruloyllupinine, octahydro-1H-quinolizin-1-ylmethyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate, 2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-ylmethyl 3-[3-methoxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphenyl]prop-2-enoate, 2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-ylmethyl 3-[3-methoxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-enoate, Nupharolutine, [(3R,6S,9R,9aS)-6-(furan-3-yl)-9-methyl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-3-yl]methanol, (3R,9S,9aR)-6-(furan-3-yl)-3,9-dimethyl-2,3,4,8,9,9a-hexahydro-1H-quinolizine, (16-oxo-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecan-4-yl) 1H-pyrrole-2-carboxylate, [(1S,2S,9aR)-2-hydroxy-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-yl]methyl 1H-pyrrole-2-carboxylate, [(1S,2S,4S,9S,10R,12R,13S)-12,13-dihydroxy-14-oxo-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecan-4-yl] 1H-pyrrole-2-carboxylate

What it is Filled

A class of alkaloids containing a quinolizidine ring system, found mainly in legumes of the family Fabaceae, especially lupins (Lupinus) and related genera; examples include lupinine, sparteine, lupanine and cytisine.

Why it exists Filled

Let an agent describe quinolizidine alkaloids, their sources, structures and toxicity in general terms, and point to food safety guidance, without giving medical advice.

Distinguishing features Filled

  • Bitter lupins contain high levels; sweet lupin varieties have low levels.
  • Cytisine is used as a smoking cessation medicine in some countries.
  • Debittering is needed before eating bitter lupin seeds.

What robots and AI may and may not do Filled

Must not

  • give dosing advice
  • advise eating raw bitter lupins

Only with a human decision

  • suspected poisoning, which goes to poison centres

May

  • describe chemistry and point to food safety guidance

Moral aspects Filled

  • food safety

Who is affected

  • consumers
  • farmers

Owners Filled

Steward

nobody; a compound class

Master systems

  • ChEBI
  • PubChem

Links to other meta-models Filled

parent

  • Q70702 - registry parent class
  • Q76516005 - registry parent class

related

  • alkaloid - chemistry
  • lupin - plant source
  • lupin poisoning - toxicity

contains

  • quinolizidine ring - structure

What else AI and robots need to interact with it Filled

Identity and identifiers required Filled

  • Vercy registry: vr.tr.quinolizidine-alkaloid
  • Wikidata: Q76515995 (https://www.wikidata.org/wiki/Q76515995)
  • ChEBI: CHEBI:26515 quinolizidine alkaloid class
  • ChEBI or PubChem: per compound individual alkaloids

Direct properties not applicable Not applicable

Not applicable

A compound class: properties belong to each compound.

Recognition required Filled

  • Appearance cannot establish identity or concentration; chromatography and mass spectrometry are used
  • Pure compounds are typically crystalline solids or oils.

Capabilities and actions required Filled

  • describe structures and examples
  • describe occurrence in lupins
  • explain food safety limits in general terms
  • point to toxicology sources

Hazards and failure modes required Filled

  • Anticholinergic poisoning from improperly debittered lupins
  • Livestock poisoning

Standards and interfaces required Filled

  • Food safety assessments of lupin alkaloids, such as the EFSA opinion (2019)
  • National limits for alkaloids in lupin foods where set

Context of use required Filled

  • Plant defence compounds; relevant to food safety of lupin products and to pharmacology.
  • lupinine type
  • sparteine and lupanine types
  • cytisine type
  • matrine type

Sources Filled

  1. Q76515995 - identity of the registry item, labels and sitelinks
  2. Quinolizidine alkaloids - class description
  3. Quinolizidine alkaloid - CHEBI:26515 - Chemical class identity and class-level identifier.
  4. Scientific opinion on quinolizidine alkaloids in feed and food, particularly lupins and lupin-derived products - 2019 assessment, structures, occurrence, analytical methods, bitter and sweet lupins, human and animal toxicity.
  5. Alkaloids and allergies: current data on health risks from lupin seeds in food - Variable alkaloid profiles and concentrations, analytical limitations and food-safety context.
  6. Cytisinicline (cytisine) - Cytisine's medicinal use for smoking cessation and its alternative name cytisinicline.

Open questions

  • The registry merges individual compounds named by systematic names; they should be separate entries.

Machine files

Card as JSON Specification Card backlog vercy.card/1

Provenance

thing registry research (pass 2) · unreviewed

Built from: models/things/publications/thing-q76515995/spec.json